Bayern Munich winger Coman will return to his club as he is not fit to take part in Monday’s Group E game at the Stade de France.
Coman had been set to start the opening match of France’s qualifying campaign against Moldova but was injured in the warm-up.
The 22-year-old’s career has been regularly affected by injury and he missed three months of action for Bayern after damaging ankle ligaments on the first weekend of the Bundesliga season.
Deschamps told a news conference no replacement would be called up for Coman, with Blaise Matuidi having taken his place in the side for a 4-1 win in Moldova.
World champions France are already without left-back Lucas Digne after he returned to Everton having sustained a thigh injury.
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